The world's unsolved problems
993 open questions across 14 fields, gathered from Wikipedia. Pick one and start thinking.
40 results in Chemistry · clear · surprise me
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Is there a scalable alternative to current industrial ammonia synthesis that operates at room temperature and atmospheric pressure?
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Can single-molecule detection be routinely achieved for non-fluorescent analytes in complex biological matrices without amplification?
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Is it possible to develop universal calibration-free sensors that maintain accuracy across varying environmental conditions and sample…
Is it possible to develop universal calibration-free sensors that maintain accuracy across varying environmental conditions and sample matrices?
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How can in operando analytical techniques bridge the “pressure gap” and “material gap” between idealized surface science models and…
How can in operando analytical techniques bridge the “pressure gap” and “material gap” between idealized surface science models and real-world catalytic interfaces?
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Can artificial intelligence fully automate the interpretation of multi-dimensional hyphenated data (e.g., LC-MS-NMR) to identify unknown…
Can artificial intelligence fully automate the interpretation of multi-dimensional hyphenated data (e.g., LC-MS-NMR) to identify unknown trace contaminants with human-expert reliability?
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Enzyme kinetics
Why do some enzymes exhibit faster-than-diffusion kinetics?
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Protein folding problem
Is it possible to predict the secondary, tertiary and quaternary structure of a polypeptide sequence based solely on the sequence and environmental information? Inverse protein-folding problem: Is it possible to design a polypeptide sequence which will...
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RNA folding problem
Is it possible to accurately predict the secondary, tertiary and quaternary structure of a polyribonucleic acid sequence based on its sequence and environment?
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Protein design
Is it possible to design highly active enzymes de novo for any desired reaction?
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Biosynthesis
Can desired molecules, natural products or otherwise, be produced in high yield through biosynthetic pathway manipulation?
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Data last refreshed 2026-10-20 03:01 UTC.